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To date, nearly a decade of research has pointed to vitamin B12 as a safe, effective treatment of depression and anxiety

Phase I biotransformation seems to be enzymes that catalyzes oxidation, reduction or hydrolyze reactions, it usually converts substrates to more polar forms by introducing or unmasking a functional group (e.g., OH, NH2, or SH)

There's also a well-documented artemisinin-free version called Artemisia Naphta oil which performed well at 1% in a small human trial for sensitive and acne-prone skin

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