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Cancer treatments significantly elevate OS through multiple mechanisms: chemotherapeutic agents, particularly alkylating agents and platinum compounds, generate excessive ROS directly damaging sperm DNA and membranes (87, 88), while radiation therapy induces both acute and chronic OS states in testicular tissue, leading to prolonged spermatogenic dysfunction (95)

CJC 1295 no DAC is a growth hormone releasing hormone analogue designed without a drug affinity complex, while ipamorelin is a selective ghrelin receptor agonist peptide

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Apr 14 2008;168(7):713-720