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[4] Based on animal research, it is thought that the increased methylmalonyl-CoA hydrolyzes to form methylmalonate (methylmalonic acid), a neurotoxic dicarboxylic acid, causing neurological deterioration

Further, GPx5, the cystine (active site) containing homotetrameric enzyme, is expressed exclusively in the epididymis to protect sperms from being damaged by hydrogen peroxide during their maturation [1, 8, 9]