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It was also reported that mitochondrial dysfunction can trigger ATF4, and thus, in our case, its activation could be secondary to IFN--mediated disturbance of the TCA cycle and respiratory activity [28]

J Clin Invest, 95: 3-12

Initially used to treat rheumatoid arthritis and multiple sclerosis, DHODH inhibitors were later found helpful in treating cancer, viral infections, and blood disorders [55,56,57,58]

Clinical evaluation: Patient history: symptoms such as weight changes, energy levels, temperature sensitivity, and emotional well-being can provide clues

Assembly of RNA polymerase II transcription initiation complexes