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Fumonisin (FB1) could also increase the ROS levels of cells by affecting the Keap1-Nrf2 pathway-related factors to cause inflammation and cell apoptosis, and finally destroy the testicular tissue structure and affect the formation of sperm [87]

441 In the absence of WNT ligands, cytoplasmic -catenin is rapidly degraded by a destruction complex, whose components contain adenomatous polyposis coli protein (APC), AXIN, casein kinase 1 (CK1), -transducin-repeat-containing protein (-TrCP), and glycogen synthase kinase 3 (GSK3) (Fig