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Even more intriguing are the systemic effects observed with topical application

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Its a multifactorial issue where poor biomechanics, chronic muscle strain, systemic inflammation from her metabolic state, and low energy production from her thyroid and vitamin deficiencies are all feeding into each other

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On the other hand, a vitamin B12 deficiency appears to cause a loss of appetite in some people, leading to weight loss rather than weight gain ( That said, the current evidence is too weak to suggest that a vitamin B12 deficiency has any strong or specific impact on weight be it weight gain or loss