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Enzymes like CD38 ramp up with age, consuming NAD+ before your cells can use it

Sugiura Y, Tamai Y, Tanaka H (1978) Selenium protection against mercury toxicity: high binding affinity of methylmercury by selenium-containing ligands in comparison with sulfur-containing ligands

The main interactions come from two mechanisms: amplified hypoglycemia risk when combined with insulin or sulfonylureas, and altered absorption of oral medications due to delayed gastric emptying