in 2023 conducted a double-blind, randomized, placebo-controlled trial that examined the oral administration of collagen dipeptides (1650 mg per day for 12 weeks) in 100 women in Korea (3060 years of age) and compared the placebo group ( n = 46) with the treatment group ( n = 54) in terms of skin hydration, elasticity, desquamation, and wrinkling [42]
This leads to the transcription of genes involved in detoxification, antioxidation, and anti-inflammatory responses ( Figure 2 ) (90)
This comprehensive approach to health makes it a suitable choice for anyone looking to optimize their physical capabilities while supporting mental clarity and emotional balance
Although these studies proposed different sources for lactylation substrates, the regulatory impact of protein lactylation on gene expression has since been widely confirmed
The regional specificity of brain GSH 13 and the relatively small sample sizes of prior studies are potential reasons for these inconsistent results