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(2024) [123] highlighted the role of glucagon-like peptide-1 (GLP-1) receptor agonists in reducing migraine frequency

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days 1 to 30): 3 mg orally once a day Dose escalation (days 31 to 60): 7 mg orally once a day Maintenance dose (day 61 and onward): If no additional glycemic control is needed: 7 mg orally once a day If additional glycemic control is needed: 14 mg orally once a day SUBCUTANEOUS: Ozempic Injection: Initial dose: 0.25 mg subcutaneously once a week for 4 weeks, then 0.5 mg subcutaneously once a week Maintenance dose: 0.5 to 2 mg subcutaneously once a week, based on glycemic control If additional glycemic control is needed after at least 4 weeks on the 0.5 mg dose: Increase to 1 mg subcutaneously once a week

VK2809, another THR agonist, reduced hepatic steatosis in mice 45 and liver lipid content in patients with MASLD (NCT02927184)