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The Gut-Brain Axis and the Vagus Nerve The GLP-1 produced in the intestines after a meal also plays a role in suppressing eating, likely through different circuits than those GLP-1-expressing neurons found in the brain stem

Recent pharmacovigilance research has identified elevated reporting odds ratios for hair loss with semaglutide (2.46) and tirzepatide (1.73), suggesting a real association between these medications and increased shedding

All three receptor systems are now meaningfully engaged

However, most degradation is invisible at the molecular level

At the highest dose, about 42 per cent of patients experienced nausea, while more than 32 per cent reported diarrhoea