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A Canadian cohort study noted an association between use of cleaning agents early in life and risk of childhood wheeze and asthma at age 3 years ( 2.1.2 Obesity Obesity is becoming increasingly common, and it is associated with an increased risk of asthma ( Obesity is also associated with co-morbidities such as depression and gastroesophageal reflux disease which can further worsen the clinical manifestations of asthma ( When obesity complicates existing asthma, patients report increased symptoms, poorer asthma control, more frequent exacerbations and a poorer quality of life, whereas weight loss increases asthma control

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We have shown that the growth of metastatic breast cancer cells in LNs imposes solid stress on HEVs and prevents the infiltration of T cells into the metastatic lesions (56) ( Figure 2 )