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The permeability of the non-targeted nanocarriers was similar in the BBB models with control (3-PLG-dopa P app : 5.73 10 6 cm/s) or PD organoids (3-PLG-dopa P app : 5.65 10 6 cm/s) in the acceptor compartment (Fig

Although metformin is extremely efficient, its absorbtion is poor and variable

Introduction Humoral alloimmunity mediated by donor-specific Human leukocyte antigen (HLA) antibodies (DSAs) is the principal cause of acute and chronic antibody mediated rejection (ABMR) leading to kidney graft damage and having a major impact on graft survival ( Despite a clear association of DSAs with ABMR and poor long term graft outcome, recipients of renal transplants from HLA-identical siblings have been reported to develop accelerated ABMR ( In addition to cell surface antigens, non-HLA antibodies may recognize cryptic antigens that become exposed after tissue damage prompted by ischemia-reperfusion, alloimmunity, and/or chronic inflammation