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Potent small-molecule binding to a dynamic hot spot on IL-2

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Embodiment 2 [0089] Example 2: Preparation of peptide c peptide resin [0090] 46.6 g of Rink Amide resin with a substitution degree of 0.43 mmol / g was weighed into a solid-phase reaction column, and swollen with DMF / DCM (1:1) for 30 minutes

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Research data shows that samples stored at minus 20 degrees Celsius retained 98 percent potency after 12 months