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Here we report the cryo-electron microscopy (cryo-EM) structures of CCK1RG s signaling complexes liganded either by sulfated cholecystokinin octapeptide (CCK-8) or a CCK1R-selective small-molecule SR146131, and CCK2RG q complexes stabilized by either sulfated CCK-8 or a CCK2R-selective ligand gastrin-17

6 CardoneM.RoyN.StennickeH.SalvesenG.FrankeT.StanbridgeE.et al

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Protocols may start low and increase or use loading doses followed by maintenance depending on peptide half-life and safety data

The mouse model used in this study presented lung resistance increase, different types of inflammatory cell infiltration dominated by eosinophils, and mucus plug formation