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Copper toxicity: the biggest concern is shown in an accumulation of Copper in the bloodstream, particularly with individuals who have preexisting diseases such as Wilson's disease

J Neurosci Res (2014) 92(4):44654

If a patient is deficient in glutathione from, for example, malnutrition, and then ingests acetaminophen, which requires glutathione as part of its metabolism, the patient loses the inhibitory effect on GGCS

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