PMID 16163497
We found no significant changes in Glu or GABA in the occipital cortex in OCD, or any evidence of correlation with behaviour or symptoms despite suggestive evidence from some other neuroimaging studies of changes in this region 42,43,44,45,46,47
However, the concentrations of both allopurinol and oxypurinol achieved during in vivo pharmacotherapy seem to be too low for their antioxidant effect (if there is any) to be of therapeutic importance (Halliwell and Gutteridge, 2015)
When to seek medical care Medical advice is important if a person has persistent fatigue, muscle weakness, exercise intolerance, poor appetite, repeated vomiting, or unexplained low blood sugar
Dosages in animal studies: In the vast majority of preclinical studies, the doses used in rats range between 10 g/kg and 10 ng/kg of body weight, administered intraperitoneally or orally