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Although cytokines are necessary for fighting infections, high levels of cytokines lead to chronic inflammation and resultant tissue injury

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4.3 Mitophagy and metabolic-associated fatty liver diseases Metabolic associated fatty liver disease (MAFLD) refers to a series of diseases caused by multi-systemic metabolic dysfunction resulting in chronic liver damage, including hepatic steatosis, NAFLD, hepatic fibrosis, liver cirrhosis, hepatocellular carcinoma, and others ( In vitro , CP upregulates the protein levels of PGC-1, PPAR, PINK1, Parkin, ATG7, and LC3I/II in free FA (FFA)-induced NAFLD cell models, activates the PINK1-Parkin signaling pathway to promote mitophagy in liver cells, and inhibits FFA-induced OS and lipid accumulation

Avoid greasy, spicy, or very sweet foods

doi: 10.1152/physrev.00035.2017 407 MurrayKBarbozaMRudeKMBrust-MascherIReardonC