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Signal Selectivity (Biased Agonism) In vitro research indicates that non-peptide GLP-1R agonists may exhibit signal bias favoring the Gs/cAMP pathway over the -arrestin pathway

Effect sizes that are dramatic in a 300-gram rodent do not always translate to a 75-kilogram human pushing off a padel court at 30 kilometres per hour

Additional reporting by Nathaniel Meyersohn