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The bioactive compounds found in these tropical plants interact with the gut microbiota and the available phytonutrients, playing a critical regulatory role in human health [193]

It can also be caused by genetic factors, obesity, high blood pressure and kidney disease

82,83 Patients may also experience paresthesia and allodynia, where non-painful stimuli are perceived as painful

This pattern holds biological significance in PD in that it suggests that disease- or treatment-related effects may exert selective pressure on the microbial network in the gut without necessarily lowering the overall number of microbial species present, thereby exerting an influence on GBA signaling and L-DOPA metabolism

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