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Bipolar disorder and inflammation

The increased endogenous opioids in the body fluids of individuals with ASD have been connected to altered activity in ASD of the DPP4 enzyme, which is able to decrease endogenous and exogenous opioid peptide levels in the blood (58)

This has led to many dosing errors by patients using compounded medications

New England Journal of Medicine , 2015;373(1):11-22

Betaine supplementation has been used for over 40 years to support individuals with genetic defects of folate dependent remethylation because betaine is known to increase methionine concentration and aid homocysteine reduction