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Patients should be advised to increase their mobility, and intake of water and fibre, as well as to consider the use of stool softeners (Figure 1, Figure 2 and Figure 3)

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Individuals suffering from kidney or liver disease should exercise caution

Second, although our data indicate that Vutiglabridin and GLP-1 RAs act through complementary mechanisms, the detailed molecular crosstalk between these pathways has not yet been fully elucidated