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Michelle Brown 2 , Bonita Basnyat 2 , Jennifer Dine 2 1 Ionis Pharmaceuticals, Carlsbad, California, USA, 2 RTI Health Solutions, Research Triangle Park, North Carolina, USA Journal of Patient-Reported Outcomes 2026 , 10(Suppl 1) :2032 Aims Severe hypertriglyceridemia (sHTG) and familial chylomicronemia syndrome (FCS) are characterized by high triglyceride levels associated with negative impacts on physical, emotional, social, and cognitive function

When PNP was inhibited pharmacologically by the compound immucillin H (ImmH), intracellular cleavage of NR to NAM was prevented, and NAD + synthesis was potentiated from NR both in vitro and in vivo 25

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