Unknown Systemic Effects : Potential for unforeseen effects on other organ systems due to systemic exposure, especially with injectable forms
10.1007/s00109-016-1488-y 30 HsuY
Supplementary information ESM 1 (download DOCX (DOCX 1210 kb) Rights and permissions Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made
Fold change and FDR values relevant for Fig 8A.[LSA-2025-03536_Supplemental_Data_2.docx] Subcellular fractionation Subcellular fractionation to separate a lysosome-enriched fraction from the cytosol was performed by employing the Sigma-Aldrich LYSISO1 Lysosome Isolation kit (Kacal & Vakifahmetoglu-Norberg, 2022), and according to the manufacturers instructions
Research from Russia and Eastern Europe, where DSIP has been studied more extensively than in the United States, has suggested the peptide may reduce withdrawal symptom severity and improve outcomes in opioid detoxification protocols