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some experts warn that altering melanin production could reduce natural photoprotection and theoretically increase UV damage risk more research is needed

ROC analyses were completed to identify cut-points for severity thresholds between anchor categories, including a) the whole population (e.g., No to Moderate versus Severe) or b) only individuals in adjacent categories (e.g., Moderate versus Severe) to estimate the threshold, first at all timepoints in a stacked dataset and then split by timepoint (Baseline/Post-Baseline)

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Garcia-Ramos A et al