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1 Introduction Selective serotonin reuptake inhibitors (SSRIs) increase extracellular serotonin levels by inhibiting the neurotransmitters reuptake by synaptic cells, thereby increasing the binding and activation of postsynaptic receptors

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2.2 Animals Eighty healthy male Sprague-Dawley (SD) rats aged 78 weeks, were purchased from Beijing WeitongLihua Laboratory Animal Technology, weighing 180 20 g