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Efficacy, Tolerability and Pharmacokinetics of Combined Targeted MEK and Dual Mtorc1/2 Inhibition in a Preclinical Model of Mucosal Melanoma

Four of the six genes investigated by quantitative RT-PCR were significantly up-regulated by Exendin-4 pre-conditioning, including Lactate dehydrogenase A ( Ldha ), Aldolase A ( Aldoa ), Phosphofructokinase ( Pfkp ) and Glucose-6-phosphate isomerase ( Gpi ) (Fig

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Lurasidone has a lower risk of weight gain and metabolic complications than many other atypical antipsychotics

However, 6 of the 12 admitted patients were exposed to supratherapeutic doses, while 4 patients reportedly injected therapeutic doses