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The therapeutic potency of such compounds is directly related to their structureactivity relationships, which control their antioxidant activity, bioavailability, and bloodbrain barrier permeability

TXNRDs are homodimeric enzymes, and each monomer contains FAD- and NADPH-binding domains and a selenocysteine-containing catalytic site

Because of the broad distribution of their receptors in the CNS, these well-characterized peptides have critical controlling roles

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inhibiting DMT1 alleviates IL-1-induced inflammatory responses and extracellular matrix degradation by significantly suppressing the MAPK and PI3K/AKT/NF-B signaling pathways (Liu et al., 2024)