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In addition, PRMT1 and PRMT5 exhibit overlapping substrate specificity, and they can competitively modify the same substrates, effectively substituting for each other to perform similar methyltransferase functions on the same substrate [21]

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Attempts to cultivate elsewhere have failed, partly due to the unique requirements needed for rooibos growth such as the type of soils, climate and biotic components in the soils (Graaff et al