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Unlike medication effects, which are usually aimed at altering action of one receptor or enzyme to ameliorate psychiatric symptoms [e.g., serotonergic pathway, glutamatergic pathway (108)], the low glutamate diet aims to reduce glutamatergic excitotoxicity while concurrently increasing consumption of nutrients known to be protective against excitotoxicity, with the aim of improving neurotransmission (69, 109)

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For lasting benefits, regular treatments may be recommended to help maintain optimal hydration and nutrient levels

Although the drug is effective, less sensitive strains are emerging

Symptoms include extreme tiredness, lack of energy, pins and needles (paraesthesia), sore and red tongue, muscle weakness, depression, and problems with memory, understanding, and judgment