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Clinical anecdotes that patients treated with semaglutide, a glucagon-like peptide-1 receptor (GLP1R) agonist approved for treating type 2 diabetes (T2D) in 2017 and for weight management in 2021 reported reduced desire to drink and smoke have attracted attention regarding its potential to treat addiction [12]

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A Yale-led randomized placebo-controlled trial in 2009 tested it specifically for fibromyalgia: both the treatment group and the placebo group improved, which suggests a strong placebo or volume-expansion effect on top of any direct nutrient benefit

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