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In general, apoptosis of granulosa cells reduces the availability of hormones and survival factors that are essential for oocytes growth and maturation, impairing oocytes meiotic and developmental competence

The ACC is implicated in error monitoring 14,15 and reward prediction errors 16,17 , which are cognitive processes critical for compulsive responses

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GHK also prevents damaging effects of lipid peroxidation, by binding its by-products such as acrolein and 4-hydroxynonenal [33,34]

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