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Cell death, oxidative stress, vascular dysfunction, cellular senescence, inflammation, release of profibrotic agents, and Reninangiotensinaldosterone system (RAAS)-activation are the putative pathomechanisms in radiation nephropathy (Table 2)

Kidd, S.A., Lancaster, P.A., Anderson, J.C., et al

The oxidant stress of hyperhomocyst(e)inemia

While there is research that supports its okay to keep water-based ascorbic acid (pure vitamin C) in the refrigerator to help prolong stability and delay in colour change, its important to note that this only applies to ascorbic acid in water