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Most clinically significant CYP3A4 inhibitors are small molecules with specific structural features (imidazole rings, macrolide lactone rings) that bind to the enzyme's active site

Psychol Assess 30(3):383 Woodcock EA, Lundahl LH, Khatib D, Stanley JA, Greenwald MK (2021) N-acetylcysteine reduces cocaine-seeking behavior and anterior cingulate glutamate/glutamine levels among cocaine-dependent individuals

Mucosal cells, which make up the gut lining, play a key role by producing glutathione (GSH), which is essential for maintaining gut barrier integrity and protecting against damage

Available from: Ozturk M, Ipekci A, Kiyak SK, et al

Scientific References European Journal of Endocrinology (1998) "Ipamorelin, the first selective growth hormone secretagogue." (The landmark study defining its selectivity)