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Tirzepatide (15 mg weekly) drives 15.7% weight loss over 72 weeks in patients with obesity and T2D (45) and 22.5% weight loss in patients with obesity alone (46)

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If GI symptoms persist despite these strategies, some users explore split dosing (microdosing) to reduce peak concentration and smooth out the dose response

Systematic reviews suggest that certain probiotic strains can modestly improve upper GI symptoms in functional dyspepsia compared with placebo, with good safety profiles overall.61 In IBS, multiple trials and reviews report small but meaningful reductions in abdominal pain, bloating, and stool irregularity for some patients, though results are strain-specific and not everyone responds.63 Spore-forming and Lactobacillus/Bifidobacterium strains are among the most studied

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