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Current research limitations include the absence of large-scale randomized clinical trials in humans, an still partial understanding of the precise molecular mechanisms, and a lack of detailed pharmacokinetic data in humans

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Pharmaceutical Executive: June 2024 Volume 44 Issue 6 Pharm Exec Exclusive: Mark Cuban Talks Drug Pricing Miranda Schmalfuhs Now more than two years into launching his alternative and transparent drug payment model, the longtime entrepreneur, in an interview with Pharm Exec, discusses the prescription drug cost landscape and shares his recipe for true disruption to the pharma pricing machine

P =0.002), and patients with end-stage renal disease showed a numerically lower hazard estimate (HR 0.15, 95% CI 0.030.67

Subsequently, this triggers further ROS production and reactivates the inflammatory cycle, exacerbating apoptosis in corneal and conjunctival epithelial cellsa process that perpetuates a vicious circle causing the progression of DED (Dammak et al., 2023)