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The cGMP that is produced via NO activation of soluble guanylate cyclase (sGC) in this tissue is degraded by a specific cyclic nucleotide phosphodiesterase (PDE) identified as PDE5A

Sikiric et al., 2020b) (in various wound models, VEGF, factor VIII, CD34 peak appear in the early interval, while later depressed (Sikiric et al., 1999a)