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For individuals with pre-existing gastrointestinal conditions such as inflammatory bowel disease, previous bowel surgery, or chronic constipation, closer monitoring may be warranted when initiating therapy

For patients with type 2 diabetes, dosage adjustments of concomitant oral and antidiabetic products may be needed

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Warning Signs Requiring Immediate Medical Attention Although minor symptoms may sometimes respond to dietary modifications and medication changes, severe manifestations necessitate prompt medical intervention

At 48 weeks, 93% of the 12 mg group had liver fat below 5%