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My Clinical Advice: How To Use Nimesulide Safely Only for short-term use: 715 days maximum Typical dose: 100 mg twice daily, after meals Avoid in patients with liver or kidney disease Not recommended for children under 12 years Never combine with other NSAIDs 5

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In some experiments, we applied receptor antagonists, an ion channel antagonist or a phosphodiesterase inhibitor to the organ baths as delineated in the figure legends and in Table 1