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Treatment with sulforaphane significantly reduced expression of key glycolytic genes, including hexokinase II and pyruvate kinase M2, in prostate cancer cell lines, LNCaP, 22RV1, and PC-3, and in transgenic mouse models, TRAMP and Hi-Myc (Singh et al., 2019)

All the results of the analytical characterization are summarized in Fig

2020;11(1):3445.[DOI] 44

Based on our data, we believe that the RESILIENCE trial would have achieved better outcome for the patients if it were designed to treat HR+ patients with Sorafenib together with hormonal therapy versus Placebo with hormonal therapy