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Insurance coverage for GLP-1 medications can be revoked, plan structures change and patients who lose access to a drug can regain weight rapidly

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In contrast to GLP-1 and oxyntomodulin, however, PYY(3-36) does not seem to have a marked effect on glucose-stimulated insulin secretion when given to human volunteers [40]

Tirzepatide starts at 2.5 mg weekly (Mounjaro), increasing by 2.5 mg every 4 weeks until the desired maintenance dose (up to 15 mg ) is reached

Given the stark difference in outcomes between the two compounds in the Marathe et al