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Kidney Int 102 , 248260 (2022) R

Serious AEs were less frequent with semaglutide, though discontinuation rates increased as baseline BMI decreased

Butyrate has anti-inflammatory properties and serves as an epigenetic regulator by activating G-protein coupled receptors (GPR41 and GPR43) and inhibiting histone deacetylase activity (Du et al., 2024)

Meanwhile, the Health Foundation, a charity, has said affluent areas of the UK see higher rates of prescriptions on average, despite lower obesity prevalence, based on data from one private provider.

But the PBMs strategies, combined with the warped incentives baked into the Inflation Reduction Act, raise questions about the viability of the biosimilar marketplace