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That said, if you're taking higher doses (15g+ daily), its smart to: Monitor digestive response Reassess needs every 812 weeks Consider lab work if taking with other supplements long-term Even high-dose glutamine supplementation has been shown to be safe for up to 6 weeks, with no adverse effects in trained subjects. Antonio, Journal of Strength and Conditioning Research Stack Timing: What to Combine LGlutamine With

Amadori A, Zamarchi R, De Silvestro G, Forza G, Cavatton G, Danieli GA, et al

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Proper patient screening, dosage, and technique minimize complications

Acute symptomatic treatment of medicinal and chemical products- induced methaemoglobinaemia