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Retatrutide Dosing Schedule (Clinical Trial Protocols) Week Range Weekly Dose Notes on Titration & Tolerability Key Points: Retatrutide is given as a once-weekly subcutaneous injection

It does this by signaling the brain to reduce hunger and increase the sensation of being full

Still, patients can manage it by staying well-hydrated, avoiding large meals, and using medications like the ondansetron mentioned above

Adverse events, primarily gastrointestinal, were mostly mild to moderate and related to dosage, with lower starting doses helping mitigate them

Branded injectables can run over $500 a month without full coverage