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Similar protective effects were detected in RA fibroblasts, where the compound reduced proliferation and attenuated the aggressive phenotype typically exhibited by these cells although in this case, the acquisition of a senescence-like phenotype was also observed ( An interesting aspect related to the therapeutic use of melanocortins is the impact of genetics on the actions of these drugs

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Another debated aspect of the anthocyanin pathway is the molecular function of anthocyanin-related glutathione transferases (arGSTs) 17,18