The third international consensus definitions for sepsis and septic shock (Sepsis-3)
Bonaventura A et al (2021) Endothelial dysfunction and immunothrombosis as key pathogenic mechanisms in COVID-19
Spinelli et al., 2010)
However, mitochondrial populations become extensively damaged by ischemiareperfusion generating excessive ROS and inflammation coupled with compromized metabolic activity and highly increased oxidative stress throughout the body causing systemic toxicity and irreversible organ damage [534]
Those systemic factors may include poor sleep, low protein intake, vitamin or mineral deficiencies, high inflammation, insulin resistance, thyroid issues, hormone changes, medication effects, excess training load, chronic stress, or inadequate rehabilitation