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Regulatory transparency is critical: Lack of clear safety or manufacturing standards can limit future investigation

Methylcobalamin at the doses used (100 mcg) is extremely well tolerated and rarely causes adverse effects on its own

There may be instances where certain conditions, such as poor nutrition, intestinal issues, infections, and cancer, may lead to B12 deficiency

If you do not have any of the conditions below then it is likely that your low vitamin B12 is due to your diet, in which case it is not a medical issue and can be corrected with oral supplements you can buy over the counter or online

doi: 10.1038/nature05026