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Importantly, these efficacy results were seen with very low rates of clinically significant hypoglycemia and a safety and tolerability profile consistent with the GLP-1 receptor agonist class. Study design For the phase 3 trial, Frias and colleagues analyzed data from 1,879 adults with type 2 diabetes inadequately controlled with metformin therapy of at least 1,500 mg daily (mean age, 57 years