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When GLP-1 drugs suppress appetite by acting on the brain's satiety centers and slow gastric emptying, they are compensating for neurological and hormonal dysregulation that does not disappear when the drug is stopped

This is the most serious risk, particularly for type 1 diabetics

In human studies examining the V H chain repertoire following pneumococcal vaccination, older adults exhibit reduced oligoclonality and a lower frequency of somatic mutations compared to younger individuals [366]

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Hauck AK, Huang Y, Hertzel AV, Bernlohr DA (2019) Adipose oxidative stress and protein carbonylation