First, severe obesity with prediabetes or T2D do not prevent the generation of HJEs and we demonstrated that these HJEs feature the cell types of an in vivo intestinal epithelium, with enterocytes, mucosecretory cells, Paneth cells and EECs, with GLP-1 cells in a controlled environment
We talked about some of the outcomes and such
Combining the validation results with the bioinformatic analysis, we therefore chose the most upregulated protein (SCD1) as the main target protein in this study
Serum leptin and adiponectin concentrations were also measured by commercially sensitive ELISA kits (Crystal Chem
Petzold A, Psotta L, Brigadski T, Endres T, Lessmann V (2015) Chronic BDNF deficiency leads to an age-dependent impairment in spatial learning