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Avoid GHK-Cu if you have Wilsons disease (due to the risk of copper accumulation), an active or history of certain cancers (due to growth factor effects and angiogenesis promotion), are pregnant or breastfeeding (safety not definitively established), or have known copper metabolism disorders or peptide allergies

These effects are associated with increased expression of the cyclin-dependent kinase inhibitors (CDKNs) p21 and p27, which are negative cell cycle regulators (Pandey et al., 2010)

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Higuchi, "Ubiquinol-10 Supplementation Activates Mitochondria Functions to Decelerate Senescence in Senescence-Accelerated Mice", Antioxid

Women with hormonal drivers (especially around perimenopause and menopause) should also get a hormone evaluation, since addressing underlying hormonal shifts is often part of an effective protocol